Anderson Group work:

Congratulations again to Richard Stenner for his two recent first author papers on the use of C45 as a de novo carbene transferase. A lovely example of designed proteins being used to expand the repertoire of possible enzyme activities into (previously!) abiotic catalysis.

A de novo peroxidase is also a promiscuous yet stereoselective carbene transferase. Stenner, R., Steventon, J. W., Seddon, A. & Anderson, J. L. R., 21 Jan 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 3, p. 1419-1428 10 p.

Chemoselective N-H insertion catalysed by a de novo carbene transferase. Stenner, R. A. & Anderson, J. L. R., 22 May 2020, In : Biotechnology and Applied Biochemistry.

Our collaborators:

Ross was also involved in some work investigating modulation of heme enzyme activity by inclusion of non-canonical amino acids in the heme binding sites. Congratulations to our collaborator Anthony Green (University of Manchester) for his paper in ACS Catalysis, which was published back in February.

Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code. Ortmayer, M., Fisher, K., Basran, J., Wolde-Michael, E. M., Heyes, D. J., Levy, C., Lovelock, S. L., Anderson, J. L. R., Raven, E. L., Hay, S., Rigby, S. E. J. & Green, A. P., 21 Feb 2020, In : ACS Catalysis. 10, 4, p. 2735-2746 12 p.

Figure 1

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