Designing better enzymes: insight from directed evolution. Bunzel HA, Anderson JLR, Mulholland AJ. Current Opinion in Structural Biology, In press.

Substrate promiscuity of a de novo designed peroxidase. Jenkins JMX, Noble CA, Mulholland AJ, Anderson JLR. Journal of Inorganic Biochemistry, In press.

Expression and in vivo loading of de novo proteins with tetrapyrrole cofactors. Curnow P, Anderson JLR. Methods in Molecular Biology, In press.

Decorated protein networks: functional nanomaterials with tunable domain size. Rios De Anda I, Coutable-Pennarun A, Brasnett C, Whitelam S, Seddon A, Russo J, Anderson JLR, Royall CP. arXiv, arXiv:1911.05857v1


Evolution of dynamical networks enhances catalysis in a designer enzyme. Bunzel HA, Anderson JLR, Hilvert D, Arcus VL, Van der Kamp MW, Mulholland AJ. BioRxiv, doi: https://doi.org/10.1101/2020.08.21.260885

Precision design of single and multi-heme de novo proteins. Hutchins GH, Noble CEM, Blackburn H, Hardy B, Landau C, Parnell AE, Yadav S, Williams C, Race PR, Oliveira SF, Crump MP, Berger-Schaffitzel C, Mulholland AJ. BioRxiv, doi: https://doi.org/10.1101/2020.09.24.311514

Controlling protein nanocage assembly with hydrostatic pressure. Le Vay K, Carter BM, Watkins DW, Tang TY, Ting VP, Coelfen H, Rambo RP, Smith AJ, Anderson JLR, Perriman AW. Journal of the American Chemical Society, 142, 49 20640-20650.

Small-residue packing motifs modulate the structure and function of a minimal de novo membrane protein. Curnow P, Hardy BJ, Dufour V, Arthur CJ, Stenner R, Hodgson LR, Verkade P, Williams C, Shoemark DK, Sessions RB, Crump MP, Jones MR, Anderson JLR. Sci Rep. 2020 10(1):15203. doi: 10.1038/s41598-020-71585-8.

Chemoselective N-H insertion catalysed by a de novo carbene transferase. Stenner RA & Anderson JLR, 22 May 2020, Biotechnology and Applied Biochemistry.

Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code. Ortmayer M, Fisher K, Basran J, Wolde-Michael EM, Heyes DJ, Levy C, Lovelock SL, Anderson JLR, Raven EL, Hay S, Rigby SEJ & Green AP, ACS Catalysis. 10, 4, p. 2735-2746 12 p.

A de novo peroxidase is also a promiscuous yet stereoselective carbene transferase. Stenner R, Steventon JW, Seddon A & Anderson JLR, Proceedings of the National Academy of Sciences of the United States of America. 117, 3, p. 1419-1428 10 p.


Photoswitchable phase separation and oligonucleotide trafficking in DNA coacervate microdroplets. Martin, N, Tian, L, Spencer, D, Coutable-Pennarun, A, Anderson, JLR, Mann S. Angewandte Chemie Intl. Ed., doi.org/10.1002/anie.201909228


Gene-Mediated Chemical Communication in Synthetic Protocell Communities. Tang, TY, Cecchi, D, Fracasso, G, Accardi, D, Coutable-Pennarun, A, Mansy, SS, Perriman, AW, Anderson, JLR & Mann, S,  ACS Synthetic Biology, vol 7., pp. 339-346

Designed for life: biocompatible de novo designed proteins and components. Grayson, KJ & Anderson, JLR,   Journal of the Royal Society Interface, vol 15.

The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity. Lalaurie, CJ, Dufour, V, Meletiou, A, Ratcliffe, S, Harland, A, Wilson, O, Vamasiri, C, Shoemark, DK, Williams, C, Arthur, CJ, Sessions, RB, Crump, MP, Anderson, JLR & Curnow, P, Scientific Reports, vol 8.

The ascent of man(made oxidoreductases). Grayson, K & Anderson, JLR, Current Opinion in Structural Biology, vol 51., pp. 149-155


Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme. Watkins, DW, Jenkins, JMX, Grayson, KJ, Wood, N, Steventon, JW, Le Vay, K, Goodwin, MI, Mullen, AS, Bailey, HJ, Crump, MP, MacMillan, F, Mulholland, AJ, Cameron, G, Sessions, RB, Mann, S & Anderson, JLR, Nature Communications, vol 8.


Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels. Armstrong, CT, Mason, P, Anderson, JLR & Dempsey, CE, Scientific Reports, vol 6.

Effect of Bioconjugation on the Reduction Potential of Heme Proteins.  Risbridger, Tom; Watkins, Dan W; Armstrong, James P; Perriman, Adam; Anderson, J L R; Fermin, David J. Biomacromolecules, Vol. 17, No. 11,  p. 3485–3492.

A suite of de novo c-type cytochromes for functional oxidoreductase engineering.  Watkins, Dan W; Armstrong, Craig T; Beesley, Joe; Marsh, Jane E; Jenkins, Jonathan M; Sessions, Richard B; Mann, Stephen; Anderson, J L R. Biochimica et Biophysica Acta – Bioenergetics, Vol. 1857, No. 5,  p. 493-502.

Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels.  Armstrong, Craig T; Mason, P.E.; Anderson, J L R; Dempsey, Christopher E. Scientific Reports, Vol. 6, 21759.


In vitro gene expression within membrane-free coacervate protocells.  Dora. Tang, T. Y.; Van Swaay, Dirk; DeMello, Andrew; Ross Anderson, J. L.; Mann, Stephen; Anderson, Ross. Chemical communications, Vol. 51, No. 57, p. 11429-11432.

Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue.  Armstrong, James P K; Shakur, Rameen; Horne, Joseph P.; Dickinson, Sally C.; Armstrong, Craig T.; Lau, Katherine; Kadiwala, Juned; Lowe, Robert; Seddon, Annela; Mann, Stephen; Anderson, J. L Ross; Perriman, Adam W.; Hollander, Anthony P. Nature Communications, Vol. 6, 7405, p. 7405.


Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site.  Armstrong, Craig T.; Anderson, J. L. Ross; Denton, Richard M. Biochemical Journal, Vol. 459, p. 369-381.

De novo protein components for oxidoreductase assembly and biological integration.  Watkins, Daniel W.; Armstrong, Craig T.; Anderson, J. L. Ross. Current Opinion in Chemical Biology, Vol. 19, p. 90-98.

Constructing a man-made c-type cytochrome maquette in vivo : electron transfer, oxygen transport and conversion to a photoactive light harvesting maquette.  Anderson, J. L. Ross; Armstrong, Craig T.; Kodali, Goutham; Lichtenstein, Bruce R.; Watkins, Daniel W.; Mancini, Joshua A.; Boyle, Aimee L.; Farid, Tammer A.; Crump, Matthew P.; Moser, Christopher C.; Dutton, P. Leslie. Chemical Science, Vol. 5, No. 2, p. 507-514.


Constructing manmade enzymes for oxygen activation.  Armstrong, Craig T.; Watkins, Daniel W.; Anderson, J. L. Ross. J.Chem Soc. Dalton Transactions, Vol. 42, No. 9, p. 3136-3150.

Elementary tetrahelical protein design for diverse oxidoreductase functions.  Farid, Tammer A; Kodali, Goutham; Solomon, Lee A; Lichtenstein, Bruce R; Sheehan, Molly M; Fry, Bryan A; Bialas, Chris; Ennist, Nathan M; Siedlecki, Jessica A; Zhao, Zhenyu; Stetz, Matthew A; Valentine, Kathleen G; Anderson, J L Ross; Wand, A Joshua; Discher, Bohdana M; Moser, Christopher C; Dutton, P Leslie. Nature Chemical Biology, Vol. 9, No. 12, p. 826-833.


In vitro gene expression and enzyme catalysis in bio-inorganic protocells.  Li, M; Green, DC; Anderson, JLR; Binks, BP; Mann, S. Chemical Science, Vol. 2, No. 9, p. 1739 – 1745.

Engineering oxidoreductases : maquette proteins designed from scratch.  Lichtenstein, Bruce R.; Farid, Tammer A.; Kodali, Goutham; Solomon, Lee A.; Anderson, J. L. Ross; Sheehan, Molly M.; Ennist, Nathan M.; Fry, Bryan A.; Chobot, Sarah E.; Bialas, Chris; Mancini, Joshua A.; Armstrong, Craig T.; Zhao, Zhenyu; Esipova, Tatiana V.; Snell, David; Vinogradov, Sergei A.; Discher, Bohdana M.; Moser, Christopher C.; Dutton, P. Leslie. Biochemical Society Transactions, Vol. 40, p. 561-566.


Manipulating cofactor binding thermodynamics in an artificial oxygen transport protein.  Zhang, L; Anderson, JLR; Ahmed, I; Norman, JA; Negron, C; Mutter, AC; Dutton, PL; Koder, RL. Biochemistry, Vol. 50, No. 47, p. 10254 – 10261.


Guidelines for tunneling in enzymes.  Moser, CC; Anderson, JLR; Dutton, PL. Biochimica et Biophysica Acta – Bioenergetics, Vol. 1797 (9), p. 1573 – 1586.

Probing the ternary complexes of indoleamine and tryptophan 2,3-dioxygenases by cryoreduction EPR and ENDOR spectroscopy.  Davydov, R.M; Chauhan, N; Thackray, S.J; Anderson, J.L.R; Papadopoulou, N.D; Mowat, N.D; Chapman, S.K; Raven, E.L; Hoffman, B.M. Journal of the American Chemical Society, Vol. 132 , No. 15, p. 5494 – 5500.


Design and engineering of O2 transport protein.  Koder, R.L; Anderson, J.L.R; Solomon, L.A; Reddy, K.A; Moser, C.C; Dutton, P.L. Nature, Vol. 458 , No. 7236, p. 305 – 310.


Controlling complexity and water penetration in functional de novo protein design.  Anderson, JLR; Koder, RL; Moser, CC; Dutton, PL. Biochemical Society Transactions, Vol. 36 (6), p. 1106 – 1111.

Rhodobactor sphaeroides haem protein: a novel cytochrome with nitric oxide dioxygenase activity.  Bor-Ran, L; Anderson, JLR; Mowat, CG; Miles, CS; Reid, GA; Chapman, SK. Biochemical Society Transactions, Vol. 36 (5), p. 992 – 995.

Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding.  Thackray, S.J; Bruckmann, C; Anderson, J.L.R; Campbell, L.P; Xiao, R; Zhao, L; Mowat, C.G; Forouhar, F; Tong, L; Chapman, S.K. Biochemistry, Vol. 47 , No. 40, p. 106777 – 106784.


The second enzyme in Pyrrolnitrin Biosynthetic pathway is related to the heme-dependent dioxygenase superfamily.  De Laurentis, Walter; Khim, Leang; Anderson, J. L. Ross; Adam, Ariane; Phillips, Robert S.; Chapman, Stephen K.; van Pee, Karl-Heinz; Naismith, James H. Biochemistry, Vol. 46, No. 43, p. 12393-12404.

Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase Forouhar, Farhad; Anderson, J. L. Ross; Mowat, Christopher G.; Vorobiev, Sergey M.; Hussain, Arif; Abashidze, Mariam; Bruckmann, Chiara; Thackray, Sarah J.; Seetharaman, Jayaraman; Tucker, Todd; Xiao, Rong; Ma, Li-Chung; Zhao, Li; Acton, Thomas B.; Montelione, Gaetano T.; Chapman, Stephen K.; Tong, Liang. Proceedings of the national academy of sciences of the united states of america, Vol. 104, No. 2, p. 473-478.


Molecular mechanisms of enzyme-catalysed halogenation.  Anderson, J. L. Ross; Chapman, Stephen K. Molecular BioSystems, Vol. 2, No. 8, p. 350-357.


Ligand probes for heme proteins.  Chapman, SK; Anderson, J L R. J.Chem Soc. Dalton Transactions, No. 1, p. 13-24.


4-Cyanopyridine, a versatile spectroscopic probe for cytochrome P450BM3.  Ost, TWB; Clark, JP; Yellowlees, LJ; Daff, S; Chapman, SK; Anderson, J L R. J. Biol. Chem, Vol. 279, No. 47, p. 48876-48882.